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Transport protein used to introduce chemical compounds into nerve cells. Inventor: A. Rummel Applicant: toxogen GmbH, Hannover filed: 6th September 2004 Application no.: DE102004043009.8; PCT/EP2005/009554 The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof. Already granted in: Europe (EP1786832), Australia, China, Mexico, Russia, Ukraine, and South Africa. Pending in USA, Canada, Israel, India, Japan, and Korea. find more: https://register.epo.org/espacenet/application?number=EP05786305
Carrier for targeting nerve cells. Inventors: A. Rummel, T. Weil, A. Gutscaits Applicant: toxogen GmbH, Hannover filed: 26th April 2005 Application no.: DE102005019302.1; PCT/EP2006/003896 The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions. Already granted in: Russia, and South Africa. Pending in Europe and USA. find more: https://register.epo.org/espacenet/application?number=EP10011509
Botulinum neurotoxin A protein receptor and uses thereof. Inventors: S. Mahrhold, A. Rummel, T. Binz, H. Bigalke Applicant: toxogen GmbH, Hannover filed 28th October 2005 Application no.: DE102005051789.7; PCT/EP2006/010420 The present invention relates to a polypeptide consisting of an amino acid sequence which is minimum 70 % identical to the amino acid sequence of the synaptic vesicle glycoprotein 2C (SV2C) from homo sapiens, but not being the synaptic vesicle glycoprotein 2C (SV2C) from homo sapiens, and the binding of this polypeptide to the HC-fragment of botulinum neurotoxin A. Already granted in: Europe (EP1940874), Australia, Mexico, New Zeeland and South Africa. Pending in USA, Canada, India, Japan, and Korea. find more: https://register.epo.org/espacenet/application?number=EP06806613
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